Show simple item record

dc.contributor.authorKilonzo, G.P.
dc.contributor.authorKaaya, S.F.
dc.contributor.authorRweikiza, J.K.
dc.contributor.authorKassam, M.
dc.contributor.authorMoshi, G.
dc.identifier.citationKilonzo, G.P. et al., (1994) Determination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzania. The Central African Journal of Medicine (CAJM), vol. 40, no.7, (pp. 178-183). UZ, Avondale, Harare: Faculty of Medicine (UZ).en
dc.descriptionA medical research paper on administering prescriptive drugs to depressed out-patience in a Dar es Salaam hospital,Tanzania.en
dc.description.abstractIn an open clomipramine dose finding study, 33 depressed indigenous African outpatients were randomly assigned to two regimens of treatment with 125 mg and 75 mg oral medications daily. At the end of eight weeks of treatment, 16 patients (48,5 pc) were on the 75 mg regime, and 17 (54,8 pc) were on 125 mg. Analysis of depression scores cm the Beck-Rafaelsen scale indicated improvements of depression in both regimes of equal magnitude. Analysis of variance showed no statistically significant difference on dose response between the two regimes. The higher doses, however, were associated with more drowsiness and tremulousness. It is suggested that Black African patients respond to tricyclic antidepressants in much lower doses than those recommended in Western textbooks. It is also apparent that side effects of tricyclic antidepressants, which have been implicated in non-compliance to medication, could be avoided without compromising treatment outcome.en
dc.publisherFaculty of Medicine, Central African Journal of Medicine (CAJM) University of Zimbabwe (UZ.)en
dc.titleDetermination of appropriate clomipramine dosage among depressed African outpatients in Dar es Salaam, Tanzaniaen
dc.rights.holderUniversity of Zimbabwe (UZ)en

Files in this item


This item appears in the following Collection(s)

Show simple item record
Except where otherwise noted, this item's license is described as