dc.contributor.author | Sarker, Protim | |
dc.contributor.author | Akhtar, Evana | |
dc.contributor.author | Kuddusi, Rakib Ullah | |
dc.contributor.author | Alam, Mohammed Mamun | |
dc.contributor.author | Haq, Md. Ahsanul | |
dc.contributor.author | Hosen, Md. Biplob | |
dc.contributor.author | Chanda, Bikash Chandra | |
dc.contributor.author | Haque, Farjana | |
dc.contributor.author | Alam, Muntasir | |
dc.contributor.author | Razzaque, Abdur | |
dc.contributor.author | Rahman, Mustafizur | |
dc.contributor.author | Ahmed, Faruque | |
dc.contributor.author | Kibria, Md. Golam | |
dc.contributor.author | Islam, Mohammed Zahirul | |
dc.contributor.author | Ahmed, Shelina | |
dc.contributor.author | Raqib, Rubhana | |
dc.coverage.spatial | Bangladesh | en |
dc.date.accessioned | 2024-02-05T18:24:33Z | |
dc.date.available | 2024-02-05T18:24:33Z | |
dc.date.issued | 2022-09 | |
dc.identifier.citation | Sarker, P.; Akhtar, E.; Kuddusi, R.U.; Alam, M.M.; Haq, M.A.; Hosen, M.B.; Chanda, B.C.; Haque, F.; Alam, M.; Razzaque, A.; Rahman, M.; Ahmed ,F.; Kibria, M.G.; Islam, M.Z.; Ahmed, S.; Raqib, R. (2022) Comparison of the Immune Responses to COVID-19 Vaccines in Bangladeshi Population, Vaccines (Basel)2022 Sep 8;10(9):1498, DOI: 10.3390/vaccines10091498 | en |
dc.identifier.uri | https://opendocs.ids.ac.uk/opendocs/handle/20.500.12413/18221 | |
dc.description.abstract | The adaptive immune response is a crucial component of the protective immunity against SARS-CoV-2, generated after infection or vaccination. Methods: We studied antibody titers, neutralizing antibodies and cellular immune responses to four different COVID-19 vaccines, namely Pfizer-BioNTech, Moderna Spikevax, AstraZeneca and Sinopharm vaccines in the Bangladeshi population (n = 1780). Results: mRNA vaccines Moderna (14,655 ± 11.3) and Pfizer (13,772 ± 11.5) elicited significantly higher anti-Spike (S) antibody titers compared to the Adenovector vaccine AstraZeneca (2443 ± 12.8) and inactivated vaccine Sinopharm (1150 ± 11.2). SARS-CoV-2-specific neutralizing antibodies as well as IFN-γ-secreting lymphocytes were more abundant in Pfizer and Moderna vaccine recipients compared to AstraZeneca and Sinopharm vaccine recipients. Participants previously infected with SARS-CoV-2 exhibited higher post-vaccine immune responses (S-specific and neutralizing antibodies, IFN-γ-secreting cells) compared to uninfected participants. Memory B (BMEM), total CD8+T, CD4+ central memory (CD4+CM) and T-regulatory (TREG) cells were more numerous in AstraZeneca vaccine recipients compared to other vaccine recipients. Plasmablasts, B-regulatory (BREG) and CD4+ effector (CD4+EFF) cells were more numerous in mRNA vaccine recipients. Conclusions: mRNA vaccines generated a higher antibody response, while a differential cellular response was observed for different vaccine types, suggesting that both cellular and humoral responses are important in immune monitoring of different types of vaccines. | en |
dc.language.iso | en | en |
dc.publisher | Vaccines (Basel) | en |
dc.relation.ispartofseries | Vaccines 10;Issue 9 | |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | Health | en |
dc.title | Comparison of the Immune Responses to COVID-19 Vaccines in Bangladeshi Population | en |
dc.type | Article | en |
dc.rights.holder | Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland. | en |
dc.identifier.externaluri | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9504987/ | en |
dc.identifier.doi | 10.3390/vaccines1009149 | |
dcterms.dateAccepted | 2022-09 | |
rioxxterms.funder | Default funder | en |
rioxxterms.identifier.project | GV/20008 CLEAR | en |
rioxxterms.version | VoR | en |
rioxxterms.versionofrecord | 10.3390/vaccines10091498 | en |
rioxxterms.funder.project | 5dfe2ceb-a69e-44d8-9dbb-809dc0332f7d | en |