Comparison of the Immune Responses to COVID-19 Vaccines in Bangladeshi Population
Download
Date
2022-09Author
Sarker, Protim
Akhtar, Evana
Kuddusi, Rakib Ullah
Alam, Mohammed Mamun
Haq, Md. Ahsanul
Hosen, Md. Biplob
Chanda, Bikash Chandra
Haque, Farjana
Alam, Muntasir
Razzaque, Abdur
Rahman, Mustafizur
Ahmed, Faruque
Kibria, Md. Golam
Islam, Mohammed Zahirul
Ahmed, Shelina
Raqib, Rubhana
Metadata
Show full item recordImpact
Abstract
The adaptive immune response is a crucial component of the protective immunity against SARS-CoV-2, generated after infection or vaccination. Methods: We studied antibody titers, neutralizing antibodies and cellular immune responses to four different COVID-19 vaccines, namely Pfizer-BioNTech, Moderna Spikevax, AstraZeneca and Sinopharm vaccines in the Bangladeshi population (n = 1780). Results: mRNA vaccines Moderna (14,655 ± 11.3) and Pfizer (13,772 ± 11.5) elicited significantly higher anti-Spike (S) antibody titers compared to the Adenovector vaccine AstraZeneca (2443 ± 12.8) and inactivated vaccine Sinopharm (1150 ± 11.2). SARS-CoV-2-specific neutralizing antibodies as well as IFN-γ-secreting lymphocytes were more abundant in Pfizer and Moderna vaccine recipients compared to AstraZeneca and Sinopharm vaccine recipients. Participants previously infected with SARS-CoV-2 exhibited higher post-vaccine immune responses (S-specific and neutralizing antibodies, IFN-γ-secreting cells) compared to uninfected participants. Memory B (BMEM), total CD8+T, CD4+ central memory (CD4+CM) and T-regulatory (TREG) cells were more numerous in AstraZeneca vaccine recipients compared to other vaccine recipients. Plasmablasts, B-regulatory (BREG) and CD4+ effector (CD4+EFF) cells were more numerous in mRNA vaccine recipients. Conclusions: mRNA vaccines generated a higher antibody response, while a differential cellular response was observed for different vaccine types, suggesting that both cellular and humoral responses are important in immune monitoring of different types of vaccines.
Citation
Sarker, P.; Akhtar, E.; Kuddusi, R.U.; Alam, M.M.; Haq, M.A.; Hosen, M.B.; Chanda, B.C.; Haque, F.; Alam, M.; Razzaque, A.; Rahman, M.; Ahmed ,F.; Kibria, M.G.; Islam, M.Z.; Ahmed, S.; Raqib, R. (2022) Comparison of the Immune Responses to COVID-19 Vaccines in Bangladeshi Population, Vaccines (Basel)2022 Sep 8;10(9):1498, DOI: 10.3390/vaccines10091498DOI
10.3390/vaccines1009149Is part of series
Vaccines 10;Issue 9Rights holder
Copyright © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Rights details
http://creativecommons.org/licenses/by/4.0/Collections
- CLEAR Bangladesh [25]